Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.55 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645161 | 0.96 | ADORA2A (0.54) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL3990423 | 0.94 | ADORA1 (0.54) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL3848060 | 0.94 | ADORA2A (0.57) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL2958488 | 0.91 | ADORA2A (0.58) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL9645114 | 0.90 | ADORA2A (0.49) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL4623457 | 0.87 | ADORA2A (0.59) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL5233098 | 0.86 | ADORA1 (0.48) | ADORA2AADORA2BADORA1 | |
| SCHEMBL4622180 | 0.86 | ADORA2A (0.48) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL9646522 | 0.85 | KDM4E (0.44) | ADORA2AADORA2BADORA1PDE4APDE4B | |
| SCHEMBL4626790 | 0.84 | ADORA2A (0.58) | ADORA2AADORA2BADORA1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0256692-B1 | 6-THIOXANTHINES | Euroceltique S.A. (LU) | 1992-09-16 | — | — | EP | disclosed |
| US-5010081-A | Bronchodilator agents | EUROCELTIQUE, S.A. (LU) | 1991-04-23 | — | — | US | disclosed |
| US-4925847-A | BRONCHODILATORS | EUROCELTIQUE, S.A. (LU) | 1990-05-15 | — | — | US | disclosed |
| EP-0256692-A2 | 6-Thioxanthines | Euroceltique S.A. (LU) | 1988-02-24 | — | — | EP | disclosed |
| US-4546182-A | TREATMENT OF RESPIRATORY AND CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET DRACO (SE) | 1985-10-08 | — | — | US | disclosed |