Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670572 | 1.00 | GSK3B (0.45) | GSK3BMAOBABCG2KDM4EALOX12 | |
| SCHEMBL7228549 | 0.81 | GSK3B (0.45) | GSK3BMAOBABCG2KDM4EAOC3 | |
| SCHEMBL4803778 | 0.79 | GSK3B (0.49) | GSK3BMAOBABCG2KDM4EALDH1A1 | |
| SCHEMBL7440354 | 0.77 | AOC3 (0.36) | GSK3BALDH1A1AOC3LMNAPKM | |
| SCHEMBL29706697 | 0.76 | GSK3B (0.54) | GSK3BMAOBABCG2KDM4EALDH1A1 | |
| SCHEMBL161792 | 0.76 | GSK3B (0.54) | GSK3BMAOBABCG2KDM4EALDH1A1 | |
| SCHEMBL10430712 | 0.75 | POLB (0.42) | HPGDAOC3HTTLMNAPOLB | |
| SCHEMBL10430946 | 0.75 | POLB (0.42) | HPGDAOC3HTTLMNAPOLB | |
| SCHEMBL10732537 | 0.75 | GSK3B (0.40) | GSK3BMAOBABCG2KDM4EALDH1A1 | |
| SCHEMBL2187434 | 0.75 | BAD (0.35) | GSK3BMAOBABCG2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5173496-A | Antiinflammatory agents | ICI PHARMA (FR) | 1992-12-22 | — | — | US | disclosed |
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | disclosed |
| EP-0284174-A1 | Therapeutic preparations | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-28 | — | — | EP | disclosed |