Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.61 |
| ▸ | RAF1 | P04049 | 12/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965583 | 0.78 | MAP2K1 (0.62) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL962144 | 0.76 | MAP2K1 (0.88) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL964533 | 0.76 | MAP2K1 (0.75) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL958789 | 0.76 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL958482 | 0.76 | MAP2K1 (0.85) | MAP2K1RAF1CYP2C9CYP3A4STS | |
| SCHEMBL973064 | 0.75 | MAP2K1 (0.72) | MAP2K1RAF1STSALDH1A2ALDH1A1 | |
| SCHEMBL959726 | 0.75 | MAP2K1 (0.72) | MAP2K1RAF1STSALDH1A2ALDH1A1 | |
| SCHEMBL965581 | 0.75 | MAP2K1 (0.81) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL960796 | 0.75 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL962007 | 0.75 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9CYP3A4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569378-B2 | p27 protein inducer | Sakai, Toshiyuki (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20110009398-A1 | p27 Protein Inducer | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009398-A1 | p27 Protein Inducer | CDKN1A, CDK2, SKP2 | MAP2K1 1179/4885RAF1 1656/4885CYP2C9 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.