Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.33 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657273 | 1.00 | KMT2A (0.37) | KMT2AMAPTNEK2TPMTGABRR1 | |
| Maleic Acid SCHEMBL9654323 | 0.78 | MAPT (0.47) | KMT2AMAPTHPGDALDH1A1PKM | |
| Fumaric Acid SCHEMBL9654328 | 0.78 | MAPT (0.47) | KMT2AMAPTHPGDALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL1310647 | 0.76 | KDM4E (0.43) | NEK2GABRR1HPGDALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL1310649 | 0.76 | KDM4E (0.43) | NEK2GABRR1HPGDALDH1A1NPSR1 | |
| SCHEMBL9654338 | 0.75 | MAPT (0.39) | KMT2AMAPTHPGDGLAALDH1A1 | |
| SCHEMBL9654346 | 0.75 | MAPT (0.39) | KMT2AMAPTHPGDGLAALDH1A1 | |
| SCHEMBL9654255 | 0.74 | KDR (0.46) | NEK2GABRR1ALDH1A1LMNATLK2 | |
| Maleic Acid SCHEMBL9656753 | 0.74 | CYP1B1 (0.53) | KMT2AMAPTHPGDHSD17B10ALDH1A1 | |
| Fumaric Acid SCHEMBL9656759 | 0.74 | CYP1B1 (0.53) | KMT2AMAPTHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084474-A | Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole | GLAXO GROUP LIMITED (GB) | 1992-01-28 | — | — | US | disclosed |
| US-5019586-A | 5-Hydroxytryptamine Receptor Antagonists | GLAXO GROUP LIMITED | 1991-05-28 | — | — | US | disclosed |
| US-4918080-A | ANXIOLYTIC AGENTS, ANTIEMETICS | GLAXO GROUP LIMITED (GB) | 1990-04-17 | — | — | US | disclosed |