Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 11/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657705 | 1.00 | HMGCR (0.43) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9655524 | 0.85 | HMGCR (0.33) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9696492 | 0.83 | HMGCR (0.39) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9696496 | 0.83 | HMGCR (0.39) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL8953087 | 0.80 | HMGCR (0.40) | HMGCRTBXA2RADRA1A | |
| SCHEMBL8953101 | 0.80 | HMGCR (0.40) | HMGCRTBXA2RADRA1A | |
| SCHEMBL8953104 | 0.80 | HMGCR (0.40) | HMGCRTBXA2RADRA1A | |
| SCHEMBL8953090 | 0.80 | HMGCR (0.40) | HMGCRTBXA2RADRA1A | |
| SCHEMBL9516800 | 0.80 | HMGCR (0.47) | HMGCRABCB11SLCO1B1HDAC1HDAC2 | |
| SCHEMBL9516811 | 0.80 | HMGCR (0.47) | HMGCRABCB11SLCO1B1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463456-A1 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and their use | E.R. SQUIBB & SONS, INC. (US) | 1992-01-02 | — | — | EP | disclosed |