Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Norepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 known ✓ | P13945 | 4/20 | 0.82 |
| ▸ | ADRB2 known ✓ | P07550 | 3/20 | 0.82 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.82 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.82 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.82 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.82 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.82 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.82 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.82 |
| ▸ | BLM | P54132 | 5/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.82 |
| ▸ | RECQL | P46063 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | APEX1 | P27695 | 3/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 3/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norepinephrine SCHEMBL9659319 | 1.00 | BLM (0.82) | BLMMAPTTDP1RECQLKDM4E | |
| L-Norepinephrine SCHEMBL9659315 | 1.00 | BLM (0.82) | BLMMAPTTDP1RECQLKDM4E | |
| Norepinephrine SCHEMBL10427348 | 1.00 | BLM (0.82) | BLMMAPTTDP1RECQLKDM4E | |
| L-Norepinephrine SCHEMBL10427349 | 1.00 | BLM (0.82) | BLMMAPTTDP1RECQLKDM4E | |
| L-Norepinephrine SCHEMBL9659893 | 1.00 | BLM (0.82) | BLMMAPTTDP1RECQLKDM4E | |
| Norepinephrine SCHEMBL2429869 | 0.91 | TDP1 (1.00) | BLMMAPTTDP1RECQLKDM4E | |
| Norepinephrine SCHEMBL29399946 | 0.91 | TDP1 (1.00) | BLMMAPTTDP1RECQLKDM4E | |
| L-Norepinephrine SCHEMBL29460319 | 0.91 | TDP1 (1.00) | BLMMAPTTDP1RECQLKDM4E | |
| Norepinephrine SCHEMBL2609 | 0.91 | TDP1 (1.00) | BLMMAPTTDP1RECQLKDM4E | |
| L-Norepinephrine SCHEMBL3489077 | 0.91 | TDP1 (1.00) | BLMMAPTTDP1RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079337-A | MACROMOLECULAR CONJUGATES OF HEMOGLOBIN, A PROCEDURE FOR THEIR PREPARATION AND THEIR USES | PASTEUR MERIEUX SERUMS ET VACCINS S.A. (FR) | 1992-01-07 | — | — | US | claimed |
| US-5110909-A | MACROMOLECULAR CONJUGATES OF HEMOGLOBIN, A PROCEDURE FOR THEIR PREPARATION AND THEIR USES | INSTITUT MERIEUX (FR) | 1992-05-05 | — | — | US | disclosed |
| US-5079337-A | MACROMOLECULAR CONJUGATES OF HEMOGLOBIN, A PROCEDURE FOR THEIR PREPARATION AND THEIR USES | PASTEUR MERIEUX SERUMS ET VACCINS S.A. (FR) | 1992-01-07 | — | — | US | disclosed |