SCHEMBL9660784

SCHEMBL9660784

Brc1cccc(CCc2ccccc2)c1

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.65
MAOB P27338 4/20 0.56
MAOA P21397 2/20 0.56
IDO1 P14902 2/20 0.52
AGXT P21549 2/20 0.52
SIGMAR1 Q99720 1/20 0.51
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
TDP1 Q9NUW8 1/20 0.48
KCNH2 Q12809 1/20 0.46
FFAR1 O14842 2/20 0.46
FFAR4 Q5NUL3 2/20 0.46
KDM1A O60341 1/20 0.46
RCOR1 Q9UKL0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4399626 0.93 TAAR1 (0.74) TAAR1MAOBIDO1AGXTSIGMAR1
SCHEMBL13569139 0.91 TAAR1 (0.61) TAAR1MAOBMAOAIDO1AGXT
SCHEMBL5139428 0.91 TAAR1 (0.61) TAAR1MAOBMAOAIDO1AGXT
SCHEMBL28585404 0.89 TAAR1 (0.59) TAAR1MAOBMAOAIDO1AGXT
SCHEMBL30444743 0.89 TAAR1 (0.59) TAAR1MAOBMAOAIDO1AGXT
SCHEMBL16203114 0.89 TAAR1 (0.59) TAAR1MAOBMAOAIDO1AGXT
SCHEMBL6500358 0.84 TAAR1 (0.63) TAAR1MAOBIDO1AGXTSIGMAR1
SCHEMBL29756502 0.84 TAAR1 (0.63) TAAR1MAOBIDO1AGXTSIGMAR1
SCHEMBL5240585 0.83 TAAR1 (0.68) TAAR1MAOBIDO1AGXTSIGMAR1
SCHEMBL27739185 0.83 TAAR1 (0.57) TAAR1MAOBIDO1AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101103034-A Amino-imidazolones for the inhibition of beta-secretase WYETH CORP (US) 2008-01-09 CN disclosed
EP-0306411-B1 ETHANONE OXIMES MITSUBISHI KASEI CORPORATION (JP) 1992-12-09 EP disclosed
US-4977151-A ANTIULCER AGENTS MITSUBISHI KASEI CORPORATION (JP) 1990-12-11 US disclosed
US-4933344-A ANTIULCER AGENTS MITSUBISHI KASEI CORPORATION (JP) 1990-06-12 US disclosed
EP-0306411-A2 Ethanone oximes MITSUBISHI KASEI CORPORATION (JP) 1989-03-08 EP disclosed