Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.78 |
| ▸ | ESR1 | P03372 | 14/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.76 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | PLD2 | O14939 | 1/20 | 0.73 |
| ▸ | ESRRB | O95718 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | ESRRG | P62508 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9661897 | 1.00 | CYP19A1 (0.78) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18840065 | 1.00 | CYP19A1 (0.78) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL10796143 | 0.94 | CYP19A1 (0.74) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL10796138 | 0.94 | CYP19A1 (0.74) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL8652610 | 0.90 | CYP19A1 (0.64) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18284333 | 0.90 | CYP19A1 (0.64) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18290928 | 0.90 | CYP19A1 (0.64) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL16233656 | 0.89 | CYP19A1 (0.82) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18291054 | 0.89 | ESR1 (0.82) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL10774708 | 0.89 | CYP19A1 (0.74) | CYP19A1ESR1ESR2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017080770-A1 | SYNTHESIS OF (Z)-ENDOXIFEN HYDROCHLORIDE | ROBERT BOSCH GESELLSCHAFT FÜR MEDIZINISCHE FORSCHUNG MBH (DE) | 2017-05-18 | — | — | WO | disclosed |
| EP-0287690-B1 | STABLE SOLVENT ADDUCTS OF Z-1-(P-BETA-DIMETHYLAMINO-ETHOXYPHENYL)-1-(P-HYDROXYPHENYL)-2-PHENYLBUT-1-ENE | HEUMANN PHARMA GMBH & CO (DE) | 1992-09-02 | — | — | EP | disclosed |
| US-4973755-A | ANTIESTROGENS | HEUMANN PHARMA GMBH & CO. (DE) | 1990-11-27 | — | — | US | disclosed |
| EP-0287690-A1 | Stable solvent adducts of Z-1-(p-beta-dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-ene | HEUMANN PHARMA GMBH & CO (DE) | 1988-10-26 | — | — | EP | disclosed |