SCHEMBL9664150

SCHEMBL9664150

Cc1nc2cc(C(c3cccc(F)c3)n3ccnc3)ccc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 12/20 0.51
CYP11B1 P15538 1/20 0.46
CYP11B2 P19099 1/20 0.46
CYP26A1 O43174 4/20 0.46
CYP3A4 P08684 2/20 0.45
CYP2C8 P10632 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP24A1 Q07973 1/20 0.45
CYP26B1 Q9NR63 1/20 0.45
CYP17A1 P05093 3/20 0.45
MEN1 O00255 1/20 0.41
NR1I2 O75469 1/20 0.41
USP2 O75604 1/20 0.41
ABCB11 O95342 1/20 0.41
ALDH1A1 P00352 1/20 0.41
PLA2G1B P04054 1/20 0.41
TP53 P04637 1/20 0.41
PGR P06401 1/20 0.41
HSP90AA1 P07900 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Irtemazole SCHEMBL9717354 0.89 CYP26A1 (0.57) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
Irtemazole SCHEMBL7453697 0.89 CYP26A1 (0.57) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
SCHEMBL9663550 0.87 CYP19A1 (0.65) CYP19A1CYP26A1CYP3A4CYP2C8CYP2D6
SCHEMBL10102742 0.83 CYP11B1 (0.46) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
SCHEMBL9198548 0.82 CYP19A1 (0.51) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
SCHEMBL9665022 0.80 CYP19A1 (0.63) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
SCHEMBL19054891 0.80 CYP17A1 (0.54) CYP19A1CYP11B1CYP11B2CYP26A1CYP17A1
Irtemazole SCHEMBL636285 0.80 CYP26A1 (0.57) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4
Hydrochloric Acid SCHEMBL9664030 0.79 CYP17A1 (0.53) CYP19A1CYP11B1CYP11B2CYP26A1CYP17A1
SCHEMBL9196344 0.78 CYP19A1 (0.55) CYP19A1CYP11B1CYP11B2CYP26A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0260744-B1 (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1992-12-16 EP disclosed
US-4859684-A (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders JANSSEN PHARMACEUTICA N.V. (BE) 1989-08-22 US disclosed
EP-0260744-A2 (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1988-03-23 EP disclosed