Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7148530 | 0.84 | CYP3A4 (0.72) | HPGDALDH1A1GAAMAPTCYP1A2 | |
| SCHEMBL25226114 | 0.83 | HPGD (0.68) | HPGDALDH1A1KDM4ETDP1CYP1A2 | |
| SCHEMBL6286095 | 0.83 | CTNNB1 (0.60) | HPGDALDH1A1KDM4EGAAMAPT | |
| SCHEMBL3253168 | 0.79 | NAPRT (0.74) | KDM4EMAPTCYP1A2CYP3A4NAPRT | |
| SCHEMBL7585683 | 0.78 | KDM4E (0.58) | HPGDALDH1A1KDM4EGAAMAPT | |
| SCHEMBL28999862 | 0.77 | CYP1A2 (0.64) | HPGDALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7830628 | 0.76 | CTNNB1 (0.55) | HPGDALDH1A1KDM4EGAAMAPT | |
| SCHEMBL3005452 | 0.76 | CYP3A4 (0.66) | HPGDALDH1A1GAACYP1A2CYP3A4 | |
| SCHEMBL7864864 | 0.76 | HPGD (0.54) | HPGDALDH1A1KDM4EGAAMAPT | |
| SCHEMBL5332989 | 0.76 | HPGD (0.83) | HPGDALDH1A1TDP1NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0149884-B1 | 5-PYRIDYL-1,3-THIAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-4612321-A | 5-pyridyl-1,3-thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0149884-A2 | 5-Pyridyl-1,3-thiazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1985-07-31 | — | — | EP | disclosed |