Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.82 |
| ▸ | FYN | P06241 | 2/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.82 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.82 |
| ▸ | PGR | P06401 | 1/20 | 0.82 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.82 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498645 | 1.00 | CYP3A4 (0.82) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL11381040 | 0.94 | CYP3A4 (0.72) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL1151809 | 0.93 | CYP3A4 (0.83) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL15927829 | 0.92 | CYP3A4 (0.84) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL11072879 | 0.92 | CYP3A4 (0.82) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL10498436 | 0.92 | CYP3A4 (0.84) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL11072868 | 0.92 | CYP3A4 (0.82) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL1152357 | 0.92 | CYP3A4 (0.82) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL1152907 | 0.92 | CYP3A4 (0.82) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| SCHEMBL10498504 | 0.92 | CYP3A4 (0.72) | CYP3A4LMNACYP51A1FYNNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4490530-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-12-25 | — | — | US | claimed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-9839636-B2 | Itraconazole analogues and methods of use thereof | UNIVERSITY OF CONNECTICUT (US) | 2017-12-12 | — | — | US | disclosed |
| US-20170209436-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-27 | — | — | US | disclosed |
| US-9650365-B2 | Itraconazole analogues and methods of use thereof | UNIVERSITY OF CONNECTICUT (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160340346-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-24 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-4861879-A | VAGINAL FUNGICIDE | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-29 | — | — | US | disclosed |
| US-4791111-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1988-12-13 | — | — | US | disclosed |
| US-4735942-A | FUNGICIDE, BACTERICIDE PARTICULARLY FOR UROGENITAL DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1988-04-05 | — | — | US | disclosed |
| EP-0228125-A1 | Novel derivatives of [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-07-08 | — | — | EP | disclosed |
| US-4619931-A | BACTERICIDES, FUNGICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1986-10-28 | — | — | US | disclosed |
| US-4490530-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-12-25 | — | — | US | disclosed |
| EP-0118138-A1 | ((4-(4-(4-Phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazoles and 1H-1,2,4-triazoles | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-09-12 | — | — | EP | disclosed |
| EP-0006711-B1 | HETEROCYCLIC DERIVATIVES OF (4-PHENYLPIPERAZIN-1-YL-ARYLOXYMETHYL-1,3-DIOXOLAN-2-YL)-METHYL-1H-IMIDAZOLES AND 1H-1,2,4-TRIAZOLES, PROCESSES FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-10-26 | — | — | EP | disclosed |
| US-4368200-A | BACTERICIDES, FUNGICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-11 | — | — | US | disclosed |
| US-4267179-A | AS FUNGICIDES AND BACTERICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340346-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | GLI1, SHH, SMO | CYP3A4 2373/4885LMNA 4777/4885CYP51A1 51/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | CYP3A4 444/4885LMNA 4868/4885CYP51A1 24/4885 |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | CYP3A4 444/4885LMNA 4868/4885CYP51A1 24/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | CYP3A4 444/4885LMNA 4868/4885CYP51A1 24/4885 |
| US-20170209436-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | GLI1, SHH, SMO | CYP3A4 2373/4885LMNA 4777/4885CYP51A1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.