Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 8/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663667 | 0.84 | CYP19A1 (0.44) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9527304 | 0.80 | CYP19A1 (0.50) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL10581927 | 0.79 | MAPT (0.48) | CYP19A1CYP17A1CYP26A1MAPT | |
| SCHEMBL10580748 | 0.78 | CYP19A1 (0.48) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9190592 | 0.78 | CYP17A1 (0.44) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9190602 | 0.76 | CYP17A1 (0.45) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9664929 | 0.75 | CYP19A1 (0.45) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9662810 | 0.75 | CYP17A1 (0.57) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9662303 | 0.75 | CYP19A1 (0.73) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL9662168 | 0.74 | CYP17A1 (0.44) | CYP19A1CYP17A1CYP26A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |