Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 8/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699600 | 0.83 | CYP26A1 (0.52) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10581927 | 0.81 | MAPT (0.48) | CYP26A1CYP17A1MAPTKMT2A | |
| SCHEMBL9664721 | 0.81 | CYP26A1 (0.48) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL9662998 | 0.78 | CYP17A1 (0.58) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10696926 | 0.75 | CYP26A1 (0.53) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL9663855 | 0.72 | CYP11B1 (0.50) | CYP11B1CYP11B2NPC1 | |
| SCHEMBL10697674 | 0.72 | CYP17A1 (0.52) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL9664044 | 0.72 | CYP17A1 (0.66) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL9662810 | 0.72 | CYP17A1 (0.57) | CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10582410 | 0.71 | MAPT (0.46) | CYP26A1CYP17A1CYP11B1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1020903-C | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THE PREPARATION THEREFOR | JANSSEN PHARMACEUTICA NV (BE) | 1993-05-26 | — | — | CN | disclosed |
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| CN-87106423-A | Novel (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and process for their preparation | — | 1988-04-20 | — | — | CN | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |