Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 18/20 | 0.79 |
| ▸ | PRUNE1 | Q86TP1 | 2/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | PDE8A | O60658 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066743 | 1.00 | SLC29A1 (0.79) | SLC29A1PRUNE1CRHR1KDM4EMEN1 | |
| SCHEMBL25191652 | 0.73 | SLC29A1 (0.59) | SLC29A1PRUNE1CRHR1KDM4EMEN1 | |
| SCHEMBL17857263 | 0.72 | SLC29A1 (0.54) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL11766019 | 0.72 | SLC29A1 (0.68) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL2115019 | 0.72 | SLC29A1 (0.53) | SLC29A1CRHR1MEN1LMNACYP3A4 | |
| SCHEMBL15721375 | 0.71 | SLC29A1 (0.87) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL12169523 | 0.70 | SLC29A1 (0.64) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL11986991 | 0.68 | SLC29A1 (0.48) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL25214099 | 0.67 | SLC29A1 (0.63) | SLC29A1PRUNE1KDM4EMEN1PDE2A | |
| SCHEMBL25205562 | 0.67 | SLC29A1 (0.63) | SLC29A1PRUNE1KDM4EMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460023-A4 | PYRIMIDO-PYRIMIDINE LIPOXYGENASE INHIBITING COMPOUNDS | — | 1992-04-08 | — | — | EP | disclosed |
| EP-0460023-A1 | PYRIMIDO-PYRIMIDINE LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-12-11 | — | — | EP | disclosed |
| US-4963541-A | INHIBIT BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1990-10-16 | — | — | US | disclosed |
| WO-1990009996-A1 | PYRIMIDO-PYRIMIDINE LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |