Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.55 |
| ▸ | PDE4A | P27815 | 3/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667476 | 0.87 | PDE3B (0.49) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9669040 | 0.85 | SMN1; SMN2 (0.60) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9667675 | 0.84 | KCNH2 (0.52) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9669024 | 0.84 | PDE3B (0.46) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9668932 | 0.84 | PDE3B (0.46) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL10623373 | 0.82 | PDE3B (0.66) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9669258 | 0.81 | PDE3B (0.43) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9669379 | 0.81 | PDE3B (0.45) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL1375479 | 0.81 | MAPT (0.67) | PDE4BPDE3BPDE3APDE4APDE4C | |
| SCHEMBL9667829 | 0.81 | PDE3B (0.45) | PDE4BPDE3BPDE3APDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |