Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670417 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL9670440 | 0.80 | TP53 (0.54) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL2954895 | 0.76 | HPGD (0.49) | SMN1; SMN2ALDH1A1TP53HPGDTSHR | |
| SCHEMBL10404767 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL10405140 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL9668723 | 0.69 | KDM1A (0.42) | SMN1; SMN2ALDH1A1TP53LMNATSHR | |
| SCHEMBL3155105 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL13532860 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL3155108 | 0.68 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL19559404 | 0.68 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TP53LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236263-B1 | SUBSTITUTED PYRROLIDINONES | CIBA-GEIGY AG (CH) | 1992-12-30 | — | — | EP | disclosed |
| US-4945092-A | Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as nootropics | CIBA-GEIGY CORPORATION (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0236263-A2 | Substituted pyrrolidinones | CIBA-GEIGY AG (CH) | 1987-09-09 | — | — | EP | disclosed |