Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.68 |
| ▸ | RARB | P10826 | 3/20 | 0.64 |
| ▸ | FAAH | O00519 | 6/20 | 0.62 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79521 | 1.00 | TP53 (0.70) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL9671383 | 0.98 | TP53 (0.67) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL9436019 | 0.95 | RARB (0.72) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL8943242 | 0.95 | RARB (0.72) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL9356366 | 0.95 | RARB (0.72) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL8292097 | 0.94 | TP53 (0.61) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL6899502 | 0.93 | RARB (0.69) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL11289645 | 0.91 | GAA (0.57) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL8081520 | 0.89 | TP53 (0.65) | TP53TSHRPLA2G4BRARBFAAH | |
| SCHEMBL8072237 | 0.89 | TP53 (0.65) | TP53TSHRPLA2G4BRARBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |