Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663340 | 0.85 | EGFR (0.51) | EGFRERBB2EPHX2FAAHP4HTM | |
| SCHEMBL10993215 | 0.84 | EGFR (0.60) | EGFRERBB2EPHX2P4HTMTBXA2R | |
| SCHEMBL4557833 | 0.83 | EGFR (0.53) | EGFRERBB2P4HTMKDM4EPTGS1 | |
| SCHEMBL29788449 | 0.83 | EPHX2 (0.54) | EGFRERBB2EPHX2FAAHP4HTM | |
| SCHEMBL7825039 | 0.81 | EGFR (0.54) | EGFRERBB2EPHX2P4HTMKDM4E | |
| SCHEMBL1161379 | 0.80 | EGFR (0.55) | EGFRERBB2P4HTMKDM4EPTGS1 | |
| SCHEMBL16353991 | 0.80 | EGFR (0.55) | EGFRERBB2P4HTMTBXA2RKDM4E | |
| SCHEMBL2810873 | 0.78 | EPHX2 (0.55) | EGFRERBB2EPHX2P4HTMKDM4E | |
| SCHEMBL7315907 | 0.78 | EGFR (0.57) | EGFRERBB2P4HTMKDM4EPTGS1 | |
| SCHEMBL398043 | 0.77 | TBXA2R (0.42) | TBXA2RCA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229566-B1 | 1-BENZENE SULFONYL 2-OXO-5-ALKOXY PYRROLIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINE AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |
| US-4829079-A | AMNESIA | ROUSSEL UCLAF (FR) | 1989-05-09 | — | — | US | disclosed |
| EP-0229566-A2 | 1-Benzene sulfonyl 2-oxo-5-alkoxy pyrrolidines, process for their preparation, their use as medicine and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-07-22 | — | — | EP | disclosed |