Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | HTR2C | P28335 | 3/20 | 0.66 |
| ▸ | HTR7 | P34969 | 3/20 | 0.66 |
| ▸ | HTR6 | P50406 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226763 | 0.92 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL14318600 | 0.86 | HTR2A (0.81) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL7246842 | 0.85 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL4160545 | 0.85 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL16481601 | 0.84 | HTR2A (0.71) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9726195 | 0.84 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9396999 | 0.84 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL11939045 | 0.84 | HTR2A (0.69) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL9670980 | 0.83 | HTR2A (0.64) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL11932544 | 0.83 | HTR2A (0.64) | HTR2AHTR2CHTR7HTR6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184258-B1 | NOVEL DERIVATIVES OF HYDROXY- OR AMINO-SUBSTITUTED (PIPERIDINYLALKYL)QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-05-06 | — | — | EP | disclosed |
| US-4665075-A | ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-05-12 | — | — | US | disclosed |