SCHEMBL9675660

SCHEMBL9675660

CCN(CC)CCCCC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21

nearest known ligand 0.81

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 5/20 0.67
CHRM4 P08173 3/20 0.67
CHRM1 P11229 3/20 0.67
CHRM3 P20309 3/20 0.67
CHRM5 P08912 2/20 0.67
ALOX15 P16050 2/20 0.67
DRD1 P21728 1/20 0.67
DRD5 P21918 1/20 0.67
TMEM97 Q5BJF2 1/20 0.67
CYP1A2 P05177 2/20 0.65
CYP3A4 P08684 2/20 0.65
MAPK1 P28482 1/20 0.65
MEN1 O00255 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C9 P11712 1/20 0.57
CYP2C19 P33261 1/20 0.57
KMT2A Q03164 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9674409 0.98 CHRM2 (0.65) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9676527 0.94 CHRM2 (0.67) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9675771 0.93 CHRM2 (0.61) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9675382 0.92 CHRM2 (0.58) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9674210 0.90 CHRM2 (0.62) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9675477 0.90 CYP1A2 (0.58) CHRM2CHRM4CHRM1CHRM3CYP1A2
Hydrochloric Acid SCHEMBL9674661 0.89 CHRM2 (0.63) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9675992 0.88 CYP1A2 (0.60) CHRM2CHRM4CHRM1CHRM3CYP1A2
SCHEMBL9728148 0.88 CHRM2 (0.81) CHRM2CHRM4CHRM1CHRM3CHRM5
SCHEMBL9674004 0.86

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306698-B1 CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THESE COMPOUNDS Dr. Karl Thomae GmbH (DE) 1992-03-25 EP disclosed
US-4931436-A BRADYCARDIAL AGENTS DR. KARL THOMAE GMBH (DE) 1990-06-05 US disclosed
EP-0306698-A1 Condensed diazepinones, processes for their preparation, and medicaments containing these compounds Dr. Karl Thomae GmbH (DE) 1989-03-15 EP disclosed