Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.75 |
| ▸ | PDE4A | P27815 | 5/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9140500 | 0.86 | PDE4A (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9140491 | 0.86 | PDE4A (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9138868 | 0.86 | PDE4A (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Adibendan SCHEMBL613156 | 0.86 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143550 | 0.85 | PDE4A (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9140828 | 0.85 | PDE4A (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143541 | 0.85 | PDE4A (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9140825 | 0.85 | PDE4A (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143986 | 0.83 | NPC1 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143976 | 0.83 | PDE4A (0.54) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496753-A1 | 2-BICYCLO-BENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND DRUGS CONTAINING SAID COMPOUNDS | Roche Diagnostics GmbH (DE) | 1992-08-05 | — | — | EP | disclosed |
| WO-1991004974-A1 | 2-BICYCLO-BENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND DRUGS CONTAINING SAID COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1991-04-18 | — | — | WO | disclosed |