Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 17/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641415 | 0.83 | KDM1A (0.36) | — | |
| SCHEMBL9641488 | 0.83 | HRH3 (0.64) | DRD4HRH3EPHX2PDK1 | |
| Hydrochloric Acid SCHEMBL9640901 | 0.82 | HRH3 (0.62) | DRD4HRH3EPHX2PDK1 | |
| Hydrochloric Acid SCHEMBL9640978 | 0.82 | KDM1A (0.36) | — | |
| SCHEMBL14208023 | 0.68 | HRH3 (0.68) | DRD4HRH3PDK1 | |
| SCHEMBL10747239 | 0.68 | HTR2C (0.36) | DRD4EPHX2 | |
| SCHEMBL1943731 | 0.68 | DRD4 (0.44) | DRD4HRH3EPHX2PDK1 | |
| SCHEMBL17166229 | 0.67 | EPHX2 (0.52) | DRD4HRH3EPHX2PDK1 | |
| SCHEMBL2296807 | 0.67 | DRD3 (0.47) | — | |
| SCHEMBL2295365 | 0.67 | DRD3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290122-B1 | MORPHOLINE DERIVATIVES AND THEIR USE | BEECHAM GROUP PLC (GB) | 1992-12-23 | — | — | EP | claimed |