Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CD44 | P16070 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30610429 | 1.00 | SYK (0.48) | SYKALDH1A1APPCCNE2CDK4 | |
| SCHEMBL27567027 | 0.90 | TDP1 (0.50) | ALDH1A1APPCCNE2CDK4CCND1 | |
| SCHEMBL12843389 | 0.88 | SYK (0.53) | SYKALDH1A1APPRAB9ANPC1 | |
| SCHEMBL25011940 | 0.83 | CD44 (0.54) | ALDH1A1HPGDSMN1; SMN2TDP1CYP3A4 | |
| SCHEMBL3794694 | 0.83 | NPC1 (0.51) | ALDH1A1APPCCNE2CDK4CCND1 | |
| SCHEMBL2940196 | 0.81 | HDAC4 (0.50) | ALDH1A1APPCCNE2CDK4CCND1 | |
| SCHEMBL28724319 | 0.81 | TDP1 (0.54) | ALDH1A1APPRAB9ANPC1POLB | |
| Hydrochloric Acid SCHEMBL2934691 | 0.80 | HDAC4 (0.49) | ALDH1A1APPCCNE2CDK4CCND1 | |
| SCHEMBL9681003 | 0.79 | CD44 (0.50) | ALDH1A1SMN1; SMN2TDP1PARP1CYP3A4 | |
| SCHEMBL3789888 | 0.79 | CD44 (0.50) | ALDH1A1APPRAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153226-A | Administering as anticholesterol agents, for atherosclerosis | WARNER-LAMBERT COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0415413-A1 | Acat inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |