Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743639 | 1.00 | HRH3 (0.70) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL27973822 | 0.97 | HRH3 (0.75) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL9678968 | 0.97 | HRH3 (0.75) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL9677945 | 0.97 | HRH3 (0.75) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL31518833 | 0.97 | HRH3 (0.75) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL9680108 | 0.97 | HRH3 (0.75) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL27008290 | 0.97 | HRH3 (0.65) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| Bromide SCHEMBL22664299 | 0.95 | HRH3 (0.71) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| SCHEMBL27885747 | 0.95 | HRH3 (0.70) | HRH3MAPTSIGMAR1CXCR4CYP1A2 | |
| Bromide SCHEMBL4670073 | 0.95 | HRH3 (0.62) | HRH3MAPTSIGMAR1CXCR4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344543-B1 | CONDENSED DIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1992-07-22 | — | — | EP | disclosed |
| US-5006522-A | Vagal pacemaker for treatment of bradycardia or radyarrhythmia | KARL THOMAE GMBH (DE) | 1991-04-09 | — | — | US | disclosed |
| EP-0344543-A2 | Condensed diazepinones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |