Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylcarbate SCHEMBL9680345 | 1.00 | GAA (0.40) | GAAHTTPOLBMEN1KMT2A | |
| Dimethylcarbate SCHEMBL9679881 | 0.90 | POLB (0.33) | HTTPOLBTSHRLMNAALDH1A1 | |
| Dimethylcarbate SCHEMBL9679888 | 0.90 | POLB (0.33) | HTTPOLBTSHRLMNAALDH1A1 | |
| Dimethylcarbate SCHEMBL9679403 | 0.89 | HTT (0.34) | HTTPOLBTSHRLMNAALDH1A1 | |
| Dimethylcarbate SCHEMBL9681075 | 0.89 | HTT (0.34) | HTTPOLBTSHRLMNAALDH1A1 | |
| Dimethylcarbate SCHEMBL9679397 | 0.89 | HTT (0.34) | HTTPOLBTSHRLMNAALDH1A1 | |
| Dimethylcarbate SCHEMBL9681079 | 0.89 | HTT (0.34) | HTTPOLBTSHRLMNAALDH1A1 | |
| SCHEMBL9017897 | 0.89 | GAA (0.42) | GAAHTTPOLBMEN1KMT2A | |
| SCHEMBL9017894 | 0.89 | GAA (0.42) | GAAHTTPOLBMEN1KMT2A | |
| Dimethylcarbate SCHEMBL9680307 | 0.87 | KDM4E (0.30) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |