Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.63 |
| ▸ | PI4KA | P42356 | 4/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.56 |
| ▸ | AHCY | P23526 | 4/20 | 0.55 |
| ▸ | ADA | P00813 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.52 |
| ▸ | GAPDH | P04406 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | STAT6 | P42226 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10442802 | 1.00 | ADORA2A (0.63) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL9491956 | 1.00 | ADORA2A (0.63) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL9679986 | 1.00 | ADORA2A (0.63) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL10442314 | 0.85 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL9680766 | 0.85 | ADORA2A (0.46) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL14231309 | 0.84 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL4981118 | 0.84 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL14399994 | 0.84 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL20224919 | 0.82 | ADORA2A (0.49) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL9491498 | 0.82 | ADCY5 (0.50) | ADORA2AADORA3ADORA1ADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383239-A1 | Isomeric dideoxynucleosides, their preparation and their use in medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-22 | — | — | EP | claimed |
| US-5126347-A | Autoimmune deficiency syndrome | HOFFMANN-LA ROCHE INC. (US) | 1992-06-30 | — | — | US | disclosed |
| EP-0383239-A1 | Isomeric dideoxynucleosides, their preparation and their use in medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-22 | — | — | EP | disclosed |