Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.63 |
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805165 | 0.81 | POLB (0.68) | POLBMCOLN3CNR2CNR1LMNA | |
| SCHEMBL6832001 | 0.79 | POLB (0.79) | POLBMCOLN3LMNAALDH1A1CYP3A4 | |
| SCHEMBL69171 | 0.77 | PSEN1 (0.61) | POLBMCOLN3CNR2CNR1ALDH1A1 | |
| SCHEMBL29368302 | 0.77 | PSEN1 (0.61) | POLBMCOLN3CNR2CNR1ALDH1A1 | |
| SCHEMBL6831728 | 0.76 | POLB (0.74) | POLBMCOLN3LMNAALDH1A1CYP3A4 | |
| SCHEMBL6833255 | 0.74 | POLB (0.71) | POLBMCOLN3LMNAALDH1A1CYP3A4 | |
| SCHEMBL6828377 | 0.74 | PSEN1 (0.50) | POLBMCOLN3CNR2ALDH1A1MAPT | |
| SCHEMBL6831183 | 0.73 | C5AR1 (0.58) | POLBMCOLN3MAPTKDM4EHPGD | |
| SCHEMBL6554749 | 0.73 | PSEN1 (0.59) | POLBCNR2CNR1LMNAALDH1A1 | |
| SCHEMBL6833224 | 0.72 | PSEN1 (0.48) | POLBMCOLN3CNR2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |