SCHEMBL9682605

SCHEMBL9682605

Cc1cc(N)c(Cl)cc1N.Nc1ccc(Cl)c(N)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 3/20 0.56
CYP3A4 P08684 6/20 0.52
CD44 P16070 1/20 0.50
GAA P10253 1/20 0.48
TSHR P16473 6/20 0.46
TP53 P04637 1/20 0.45
MAPK1 P28482 1/20 0.44
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA12 O43570 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
PLA2G7 Q13093 1/20 0.42
ALDH1A1 P00352 5/20 0.41
THRB P10828 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
RECQL P46063 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29683620 0.85 GAA (0.67) CASP1CYP3A4CD44GAATSHR
SCHEMBL2026149 0.85 GAA (0.67) CASP1CYP3A4CD44GAATSHR
SCHEMBL9681223 0.83 CYP3A4 (0.61) CASP1CYP3A4CD44GAATSHR
Hydrochloric Acid SCHEMBL8647124 0.83 CD44 (0.64) CASP1CYP3A4CD44GAATSHR
Hydrochloric Acid SCHEMBL8647129 0.83 CD44 (0.64) CASP1CYP3A4CD44GAATSHR
SCHEMBL29371741 0.82
SCHEMBL64773 0.82
Hydrochloric Acid SCHEMBL8638704 0.80 TSHR (0.62) CASP1CYP3A4GAATSHRTP53
Water SCHEMBL27532627 0.80 TSHR (0.62) CASP1CYP3A4GAATSHRTP53
Hydrochloric Acid SCHEMBL8638708 0.80 TSHR (0.62) CASP1CYP3A4GAATSHRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5175367-A Fluorine-containing diamines, polyamides, and polyimides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-12-29 US disclosed