Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683317 | 1.00 | ABCB1 (0.47) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9787406 | 0.94 | ABCB1 (0.43) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9787404 | 0.94 | ABCB1 (0.43) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9787412 | 0.94 | ABCB1 (0.43) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9684073 | 0.91 | ABCB1 (0.50) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9684062 | 0.91 | ABCB1 (0.50) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9811937 | 0.85 | GAA (0.59) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9683362 | 0.85 | GAA (0.59) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9685205 | 0.85 | GAA (0.59) | ABCB1GAATSHRALDH1A1LMNA | |
| SCHEMBL9811936 | 0.85 | GAA (0.59) | ABCB1GAATSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |