Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683688 | 1.00 | ABCB1 (0.55) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9812089 | 0.92 | ABCB1 (0.56) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9811973 | 0.92 | ABCB1 (0.56) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9811990 | 0.92 | ABCB1 (0.56) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9812016 | 0.89 | ABCB1 (0.54) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9812027 | 0.89 | ABCB1 (0.54) | ABCB1LMNAMAPTPOLBNPSR1 | |
| SCHEMBL9685205 | 0.88 | GAA (0.59) | ABCB1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9811937 | 0.88 | GAA (0.59) | ABCB1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9683362 | 0.88 | GAA (0.59) | ABCB1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9811936 | 0.88 | GAA (0.59) | ABCB1LMNAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |