Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950901 | 0.87 | SLC2A1 (0.37) | ALDH1A1HPGDMAPTCHRM2CHRM4 | |
| SCHEMBL24299500 | 0.79 | SLC2A1 (0.33) | ALDH1A1HPGDMAPTCHRM2CHRM4 | |
| SCHEMBL950518 | 0.77 | SLC2A1 (0.32) | ALDH1A1HSD17B10MAPTCHRM2CHRM4 | |
| SCHEMBL7134219 | 0.77 | TDP1 (0.45) | TDP1ALDH1A1ALDH2HPGDCYP1A2 | |
| SCHEMBL5002428 | 0.76 | MEN1 (0.34) | MAPTCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11260442 | 0.75 | CYP1A2 (0.32) | CYP1A2MAPTSLC2A1 | |
| SCHEMBL20102190 | 0.75 | TDP1 (0.50) | TDP1 | |
| SCHEMBL6719978 | 0.74 | — | — | |
| SCHEMBL20102189 | 0.73 | TDP1 (0.42) | TDP1 | |
| SCHEMBL3823316 | 0.72 | SLC2A1 (0.32) | MAPTCHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872134-B2 | 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates | TELIK, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| WO-2009076473-A1 | 2-{[2-(SUBSTITUTED AMINO)ETHYL]SULFONYL}ETHYL N,N-BIS(2- CHLOROETHYL)PHOSPHORODIAMIDATES | TELIK, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
| US-20090156559-A1 | 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates | TELIK, INC. | 2009-06-18 | — | — | US | disclosed |
| EP-0518352-B1 | Process for forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK & CHEMICALS (JP) | 1998-04-22 | — | — | EP | disclosed |
| US-5460919-A | Process of forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5372911-A | Support having one or more hydrophilic colloidal layers, at least one layer contains pyridinium salt or derivative, quinolinium salt or derivative, or isoquinolinium salt or derivative | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1994-12-13 | — | — | US | disclosed |
| EP-0518352-A1 | Process for forming super high-contrast negative images and silver halide photographic material and developer being used therefor | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1992-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156559-A1 | 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates | PHOSPHO1, SSB, BCL9 | TDP1 1260/4885ALDH1A1 4690/4885ALDH2 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.