Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 7/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684044 | 1.00 | ADRB3 (0.44) | ADRB3ADRB1ADRB2CASRHPGD | |
| SCHEMBL9684051 | 1.00 | ADRB3 (0.44) | ADRB3ADRB1ADRB2CASRHPGD | |
| SCHEMBL9684306 | 0.86 | ADRB3 (0.56) | ADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9684313 | 0.86 | ADRB3 (0.56) | ADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9684207 | 0.82 | ADRB3 (0.53) | ADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9683356 | 0.78 | ADRB3 (0.58) | ADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL9683364 | 0.78 | ADRB3 (0.58) | ADRB3ADRB1ADRB2CYP2D6 | |
| SCHEMBL11174016 | 0.78 | ADRB3 (0.66) | ADRB3ADRB1ADRB2CYP1A2CYP2D6 | |
| SCHEMBL11174014 | 0.78 | ADRB3 (0.66) | ADRB3ADRB1ADRB2CYP1A2CYP2D6 | |
| SCHEMBL9782259 | 0.74 | ADRB3 (0.45) | ADRB3ADRB1ADRB2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |