Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813971 | 0.86 | FFAR1 (0.45) | FFAR1MEN1KMT2AMAOBSIGMAR1 | |
| SCHEMBL9813972 | 0.86 | FFAR1 (0.45) | FFAR1MEN1KMT2AMAOBSIGMAR1 | |
| SCHEMBL9813963 | 0.86 | FFAR1 (0.45) | FFAR1MEN1KMT2AMAOBSIGMAR1 | |
| SCHEMBL9813975 | 0.86 | FFAR1 (0.45) | FFAR1MEN1KMT2AMAOBSIGMAR1 | |
| SCHEMBL9782739 | 0.83 | ABCB1 (0.37) | ABCB1POLBFFAR1MEN1KMT2A | |
| SCHEMBL9683564 | 0.81 | ADRB3 (0.52) | ABCB1POLBMEN1KMT2AMAOB | |
| SCHEMBL9683556 | 0.81 | ADRB3 (0.52) | ABCB1POLBMEN1KMT2AMAOB | |
| SCHEMBL9813892 | 0.81 | MEN1 (0.46) | MEN1KMT2AMAOBADRB1ADRB2 | |
| SCHEMBL9812047 | 0.81 | ABCB1 (0.53) | ABCB1POLBMAOBADRB1CYP2D6 | |
| SCHEMBL9812066 | 0.81 | ABCB1 (0.53) | ABCB1POLBMAOBADRB1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | claimed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | claimed |
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |