Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.48 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684842 | 0.89 | AKR1B1 (0.59) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL8805167 | 0.83 | AKR1B1 (0.53) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL8319660 | 0.76 | AKR1B1 (0.54) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL9383416 | 0.75 | AKR1B1 (0.44) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL9685820 | 0.75 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL8323558 | 0.75 | AKR1B1 (0.71) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL8805641 | 0.74 | AKR1B1 (0.52) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL9871300 | 0.74 | AKR1B1 (0.52) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL8805046 | 0.74 | AKR1B1 (0.54) | AKR1B1CHRM5AKR1B10AKR1A1 | |
| SCHEMBL9729042 | 0.74 | AKR1B1 (0.50) | AKR1B1CHRM5AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |