Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.86 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | RAD52 | P43351 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685620 | 0.93 | KDM4E (1.00) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL457341 | 0.87 | KDM4E (0.81) | KDM4EALDH1A1 | |
| SCHEMBL9684732 | 0.86 | KDM4E (0.72) | KDM4EALDH1A1GLAGAAHTT | |
| Hydrochloric Acid SCHEMBL2834772 | 0.86 | KDM4E (0.79) | KDM4EALDH1A1 | |
| SCHEMBL2833853 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL9684763 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1 | |
| SCHEMBL9685745 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1 | |
| SCHEMBL9685760 | 0.82 | KDM4E (0.80) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL9685928 | 0.82 | KDM4E (0.80) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL9684726 | 0.80 | KDM4E (0.62) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | claimed |
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | disclosed |
| US-5051508-A | Antisecretory agents and enzyme inhibitors as antiulcer agents | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1991-09-24 | — | — | US | disclosed |
| EP-0307078-A1 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1989-03-15 | — | — | EP | disclosed |