Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970151 | 0.86 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL2107142 | 0.85 | BACE1 (0.47) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2118025 | 0.85 | BACE1 (0.47) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2116359 | 0.82 | BACE1 (0.41) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2116357 | 0.82 | BACE1 (0.41) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108476 | 0.82 | BACE1 (0.41) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL12851657 | 0.80 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL14299104 | 0.80 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL12694666 | 0.80 | BACE1 (0.49) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL970385 | 0.79 | BACE1 (0.72) | BACE1BACE2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009395-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009395-A1 | BACE INHIBITORS | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885KCNH2 3088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.