Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | FPR2 | P25090 | 3/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688096 | 0.98 | IDO1 (0.46) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL9688143 | 0.96 | SLC6A4 (0.41) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL6347241 | 0.92 | SLC6A4 (0.43) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL12066334 | 0.79 | IDO1 (0.68) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL27778751 | 0.75 | IDO1 (0.53) | IDO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28783367 | 0.75 | IDO1 (0.53) | IDO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL19144912 | 0.72 | IDO1 (0.64) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL16979030 | 0.71 | SLC6A4 (0.49) | IDO1SLC6A4SLC6A2FPR2PROKR1 | |
| SCHEMBL8336164 | 0.71 | DHODH (0.47) | SLC6A3 | |
| SCHEMBL28750188 | 0.71 | IDO1 (0.35) | IDO1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |