Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299358 | 0.88 | PDE4A (0.41) | TRIM24TRIM33ALDH1A1PDE4APDE4B | |
| SCHEMBL2951376 | 0.86 | PDE4A (0.42) | TRIM24TRIM33ALDH1A1PDE4APDE4B | |
| SCHEMBL473531 | 0.82 | — | — | |
| SCHEMBL3438344 | 0.79 | — | — | |
| SCHEMBL20532 | 0.79 | — | — | |
| Cyclohexane SCHEMBL15212796 | 0.76 | CA1 (0.38) | ALDH1A1CA1CA2KMT2ANPC1 | |
| SCHEMBL1472301 | 0.76 | CA1 (0.38) | ALDH1A1CA1CA2KMT2ANPC1 | |
| SCHEMBL566961 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL1162671 | 0.76 | — | — | |
| SCHEMBL21237759 | 0.76 | CA1 (0.38) | ALDH1A1CA1CA2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270494-B1 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| US-4826854-A | Certain cycloalka-(b)-pyrazolo(3,4-d)-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0270494-A2 | Certain cycloalka- [b]-pyrazolo-[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1988-06-08 | — | — | EP | disclosed |