Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.35 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011221 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL30811881 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL7011224 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL29007910 | 0.89 | NPSR1 (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL30181010 | 0.89 | NPSR1 (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL263120 | 0.87 | CYP1A2 (0.41) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL10692105 | 0.87 | MAPT (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL263121 | 0.87 | CYP1A2 (0.41) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL10692109 | 0.87 | MAPT (0.40) | MAPTMEN1KMT2ANPSR1LMNA | |
| SCHEMBL9591881 | 0.87 | MEN1 (0.32) | MAPTMEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288519-A4 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | — | 1992-04-15 | — | — | EP | disclosed |
| US-4965273-A | Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-10-23 | — | — | US | disclosed |
| US-4954507-A | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents | BRISTOL-MYERS COMPANY (US) | 1990-09-04 | — | — | US | disclosed |
| EP-0191185-B1 | QUINOLINE-CARBOXYLIC ACID DERIVATIVES | DAIICHI SEIYAKU CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |
| US-4871852-A | BACTERICIDES AGAINST GRAMNEGATIVE AND GRAMPOSITIVE | DAIICHI SEIYAKU CO., LTD. (JP) | 1989-10-03 | — | — | US | disclosed |
| EP-0288519-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | Bristol-Myers Squibb Company (US) | 1988-11-02 | — | — | EP | disclosed |
| WO-1988002627-A1 | 1-TERTIARY-ALKYL-SUBSTITUTED NAPHTHYRIDINE- AND QUINOLINE-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-04-21 | — | — | WO | disclosed |
| EP-0191185-A1 | Quinoline-carboxylic acid derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-08-20 | — | — | EP | disclosed |