Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 10/20 | 0.38 |
| ▸ | TOP2A | P11388 | 3/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10443389 | 0.93 | KCNH2 (0.53) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9372414 | 0.93 | KCNH2 (0.53) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9023245 | 0.91 | POLB (0.48) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9688775 | 0.88 | POLB (0.46) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9211257 | 0.87 | POLB (0.45) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9687720 | 0.86 | POLB (0.61) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9689407 | 0.85 | KCNH2 (0.43) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9689898 | 0.85 | KCNH2 (0.43) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL9687742 | 0.85 | KCNH2 (0.42) | POLBALDH1A1CHRM2CHRM1OPRM1 | |
| SCHEMBL10509377 | 0.85 | MEN1 (0.51) | POLBALDH1A1CHRM2CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | claimed |