SCHEMBL9688062

SCHEMBL9688062

Nc1nc(N)c(CCCNc2ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2)c(=O)[nH]1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GART P22102 20/20 0.79
ATIC P31939 2/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10419882 0.97 GART (0.80) GARTATIC
SCHEMBL10420648 0.97 GART (0.77) GARTATIC
SCHEMBL9687525 0.97 GART (0.74) GARTATIC
SCHEMBL10419875 0.97 GART (0.74) GARTATIC
SCHEMBL9687628 0.94 GART (0.75) GARTATIC
SCHEMBL9688385 0.94 GART (0.70) GARTATIC
SCHEMBL10419878 0.93 GART (0.70) GARTATIC
SCHEMBL9687536 0.93 GART (0.70) GARTATIC
SCHEMBL10521244 0.89 GART (0.71) GARTATIC
SCHEMBL9687649 0.88 GART (0.66) GARTATIC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0268377-B1 GLUTAMIC ACID DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1992-03-18 EP claimed
US-4880812-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-11-14 US claimed
EP-4720100-A1 MODIFIED VECTORS CSL Behring LLC (US) 2026-04-08 EP disclosed
US-20250354166-A1 LENTIVIRAL VECTORS USEFUL FOR THE TREATMENT OF DISEASE CSL BEHRING L L C (US) 2025-11-20 US disclosed
EP-4190339-B1 A MODULATABLE SWITCH FOR SELECTION OF DONOR MODIFIED CELLS CSL BEHRING GENE THERAPY INC (US) 2025-07-02 EP disclosed
WO-2024241281-A1 MODIFIED VECTORS CSL BEHRING L.L.C. (US) 2024-11-28 WO disclosed
CN-118103076-A Lentiviral vectors useful in the treatment of disease 美国杰特贝林生物制品有限公司 2024-05-28 CN disclosed
EP-4329822-A1 LENTIVIRAL VECTORS USEFUL FOR THE TREATMENT OF DISEASE CSL Behring L.L.C. (US) 2024-03-06 EP disclosed
US-20230355674-A1 DONOR T-CELLS WITH KILL SWITCH CSL BEHRING LLC (US) 2023-11-09 US disclosed
EP-4190339-A1 A MODULATABLE SWITCH FOR SELECTION OF DONOR MODIFIED CELLS CSL Behring Gene Therapy, Inc. (US) 2023-06-07 EP disclosed
EP-4172335-A1 DONOR T-CELLS WITH KILL SWITCH CSL Behring LLC (US) 2023-05-03 EP disclosed
CN-115997015-A Donor T cells with kill switch 美国杰特贝林生物制品有限公司 2023-04-21 CN disclosed
EP-3654994-B1 A MODULATABLE SWITCH FOR SELECTION OF DONOR MODIFIED CELLS CSL BEHRING GENE THERAPY INC (US) 2022-12-28 EP disclosed
WO-2022232191-A1 LENTIVIRAL VECTORS USEFUL FOR THE TREATMENT OF DISEASE CSL BEHRING L.L.C. (US) 2022-11-03 WO disclosed
US-20220072046-A1 MODULATABLE SWITCH FOR SELECTION OF DONOR MODIFIED CELLS CSL BEHRING GENE THERAPY INC (US) 2022-03-10 US disclosed
EP-0268377-B1 GLUTAMIC ACID DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM THE WELLCOME FOUNDATION LIMITED (GB) 1992-03-18 EP disclosed
US-4940713-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1990-07-10 US disclosed
US-4880812-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-11-14 US disclosed
EP-0268377-A2 Glutamic acid derivatives, processes and intermediates for their preparation and pharmaceutical formulations containing them THE WELLCOME FOUNDATION LIMITED (GB) 1988-05-25 EP disclosed