Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 12/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688724 | 0.93 | KCNH2 (0.41) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10685223 | 0.92 | KCNH2 (0.48) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL10368950 | 0.91 | KCNH2 (0.47) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| Hydrochloric Acid SCHEMBL10687907 | 0.91 | KCNH2 (0.47) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9687742 | 0.90 | KCNH2 (0.42) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9689721 | 0.88 | KCNH2 (0.41) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9688336 | 0.88 | KCNH2 (0.54) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9688775 | 0.85 | POLB (0.46) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10683318 | 0.85 | KCNH2 (0.37) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10679948 | 0.85 | KCNH2 (0.49) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265230-B1 | SUBSTITUTED-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS, DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS, AND PROCESSES FOR PRODUCING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-01-08 | — | — | EP | claimed |