Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296694 | 1.00 | TSHR (0.46) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL9688425 | 1.00 | TSHR (0.46) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL9688480 | 0.98 | CYP19A1 (0.47) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL4290379 | 0.95 | HRH3 (0.51) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL4290125 | 0.88 | HRH3 (0.58) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL4290121 | 0.88 | HRH3 (0.58) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL4290117 | 0.88 | HRH3 (0.58) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL7022067 | 0.88 | HRH3 (0.58) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10721752 | 0.86 | HRH3 (0.57) | TSHRHRH3CYP19A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL4294092 | 0.86 | HRH3 (0.57) | TSHRHRH3CYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237169-B1 | 5-SUBSTITUTED OCTAHYDROINDOLIZINE ANALGESICS COMPOUNDS AND 7-KETO INTERMEDIATES | McNeilab, Inc. (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0237169-A1 | 5-Substituted octahydroindolizine analgesics compounds and 7-keto intermediates | McNeilab, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4689329-A | 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates | MCNEILAB, INC. (US) | 1987-08-25 | — | — | US | disclosed |