Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689179 | 1.00 | TLR3 (0.45) | TLR3AKR1B1KDM1ASIRT2CHRNB4 | |
| SCHEMBL621018 | 0.82 | KDM1A (0.38) | AKR1B1KDM1ACHRNB4CHRNA3NR3C1 | |
| SCHEMBL27280217 | 0.81 | TLR3 (0.43) | TLR3AKR1B1SIRT2CHRNB4CHRNA3 | |
| SCHEMBL7479500 | 0.77 | HTR2C (0.42) | AKR1B1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL8795599 | 0.77 | AKR1B1 (0.44) | TLR3AKR1B1SIRT2NR3C1SMN1; SMN2 | |
| SCHEMBL8795728 | 0.77 | AKR1B1 (0.44) | TLR3AKR1B1SIRT2ARSMN1; SMN2 | |
| SCHEMBL3409160 | 0.76 | CNR1 (0.48) | KDM1ASIRT2SMN1; SMN2MAPTLMNA | |
| SCHEMBL3322619 | 0.76 | TRPV1 (0.41) | AKR1B1KDM1ACYP3A4 | |
| Hydrochloric Acid SCHEMBL6561142 | 0.76 | HTR2C (0.41) | AKR1B1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL6024931 | 0.76 | TRPV1 (0.41) | AKR1B1KDM1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140031-A | Pyranyl cyanoguanidine derivatives | E. R. SQUIBB & SONS, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0401010-A2 | Pyranyl cyanoguanidine derivatives | E.R. Squibb & Sons, Inc. (US) | 1990-12-05 | — | — | EP | disclosed |