SCHEMBL9689889

SCHEMBL9689889

CCOC(=O)C[C@@H](C)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.43
PIN1 Q13526 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NPC1 O15118 1/20 0.38
PPID Q08752 1/20 0.38
F2 P00734 1/20 0.38
HSD11B1 P28845 1/20 0.38
POLB P06746 1/20 0.38
PRNP P04156 2/20 0.37
RXFP1 Q9HBX9 1/20 0.37
MMP8 P22894 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29198555 1.00 TSHR (0.43) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL29925577 1.00 TSHR (0.43) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL9347640 0.90 TSHR (0.44) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL2915808 0.87 TSHR (0.41) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL2915807 0.87 TSHR (0.41) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL23529640 0.87 TSHR (0.41) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL30879175 0.87 POLB (0.41) ALDH1A1PIN1PPIDPOLB
SCHEMBL29772371 0.87 TSHR (0.41) TSHRALDH1A1PIN1MEN1KMT2A
SCHEMBL5830575 0.86 KCNA5 (0.42) TSHRALDH1A1KMT2A
SCHEMBL3779621 0.86 KCNA5 (0.42) TSHRALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0520292-A1 Chiral azetidinone derivatives and their use as dopants in liquid crystalline mixtures HOECHST AKTIENGESELLSCHAFT (DE) 1992-12-30 EP disclosed