Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10753257 | 0.86 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL15563004 | 0.86 | PDE4A (0.56) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL1043260 | 0.84 | PDE4A (0.54) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL2321997 | 0.84 | PDE4A (0.54) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL11390862 | 0.84 | PDE4A (0.54) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL2988031 | 0.81 | PDE4A (0.42) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL11404227 | 0.81 | PDE4A (0.61) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL612464 | 0.79 | PDE4A (0.44) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL6361709 | 0.76 | PDE4A (0.38) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 | |
| SCHEMBL1133254 | 0.76 | PDE4A (0.59) | PDE4AUSP2SLCO1B1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157134-A | HMG-COA reductase inhibitors; antilipemic agents; promotes high-density lipoproteins; antitumor agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |