SCHEMBL9690490

SCHEMBL9690490

CCCCOc1ccc(C=CC2=NCCc3ccccc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.49
AHR P35869 1/20 0.46
ATP4A P20648 9/20 0.43
ATP4B P51164 9/20 0.43
CHRNA7 P36544 3/20 0.42
CHRNA10 Q9GZZ6 2/20 0.42
CHRNA9 Q9UGM1 2/20 0.42
RELA Q04206 1/20 0.42
MAPT P10636 2/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
HPGD P15428 1/20 0.42
ALOX15 P16050 1/20 0.42
KMT2A Q03164 1/20 0.42
HSD17B10 Q99714 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9690488 1.00 SLC2A1 (0.49) SLC2A1AHRATP4AATP4BCHRNA7
SCHEMBL9692864 0.85 SLC2A1 (0.61) SLC2A1AHRCHRNA7CHRNA10CHRNA9
SCHEMBL9690770 0.85 SLC2A1 (0.61) SLC2A1AHRCHRNA7CHRNA10CHRNA9
Hydrochloric Acid SCHEMBL9690465 0.84 SLC2A1 (0.60) SLC2A1AHRCHRNA7CHRNA10CHRNA9
Hydrochloric Acid SCHEMBL9690461 0.84 SLC2A1 (0.60) SLC2A1AHRCHRNA7CHRNA10CHRNA9
SCHEMBL9692527 0.84 SLC2A1 (0.57) SLC2A1AHR
SCHEMBL9692535 0.84 SLC2A1 (0.57) SLC2A1AHR
SCHEMBL9693003 0.82 SLC2A1 (0.58) SLC2A1AHRCHRNA7CHRNA10CHRNA9
SCHEMBL9693001 0.82 SLC2A1 (0.58) SLC2A1AHRCHRNA7CHRNA10CHRNA9
SCHEMBL9690487 0.82 SLC2A1 (0.60) SLC2A1AHRATP4AATP4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0170524-B1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-07-15 EP claimed
EP-0170524-A2 Nitrogen containing heterocyclic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1986-02-05 EP claimed
EP-0170524-B1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS THE WELLCOME FOUNDATION LIMITED (GB) 1992-07-15 EP disclosed
US-4968698-A FUNGICIDES, ANTIPROTOZOA AGENTS BURROUGHS WELLCOME CO. (US) 1990-11-06 US disclosed
EP-0170524-A2 Nitrogen containing heterocyclic compounds THE WELLCOME FOUNDATION LIMITED (GB) 1986-02-05 EP disclosed