SCHEMBL9699683

SCHEMBL9699683

C[C](Cc1n[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.46
CYP3A4 P08684 1/20 0.46
ROCK2 O75116 4/20 0.42
ROCK1 Q13464 4/20 0.42
PARP1 P09874 1/20 0.42
PARP3 Q9Y6F1 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
EGFR P00533 1/20 0.41
MME P08473 3/20 0.41
RPS6KA5 O75582 1/20 0.41
RPS6KA4 O75676 1/20 0.41
PRKACA P17612 1/20 0.41
GSK3A P49840 1/20 0.41
GSK3B P49841 1/20 0.41
IRAK1 P51617 1/20 0.41
PRKX P51817 1/20 0.41
PRKG1 Q13976 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7663084 0.77 CYP3A4 (0.41) MAPK1CYP3A4ROCK2ROCK1PARP1
SCHEMBL8829870 0.76 EGFR (0.49) MAPK1CYP3A4ROCK2ROCK1PARP1
SCHEMBL9699633 0.74 MAPK1 (0.47) MAPK1CYP3A4ROCK2ROCK1PARP1
SCHEMBL4330755 0.73 MAPK1 (0.68) MAPK1CYP3A4ROCK2ROCK1NPC1
SCHEMBL8894924 0.72 KMT2A (0.54) MAPK1CYP3A4NPC1ALDH1A1RAB9A
SCHEMBL9399648 0.72 CYP1A2 (0.48) MAPK1CYP3A4ROCK2ROCK1PARP1
SCHEMBL8829857 0.71 KDM4E (0.51) MAPK1CYP3A4ALDH1A1KDM4EMEN1
SCHEMBL8893001 0.71 ECE1 (0.53) MAPK1CYP3A4ALDH1A1KDM4EMEN1
SCHEMBL2089507 0.70 MAPK1 (0.69) MAPK1CYP3A4ROCK2ROCK1NPC1
SCHEMBL892377 0.70 MAPK1 (0.64) MAPK1CYP3A4ROCK2ROCK1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992004025-A1 AMINO ACID ANALOGS AS CCK ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1992-03-19 WO disclosed