SCHEMBL9701252

SCHEMBL9701252

CCCc1cc2cccnc2n1S(=O)(=O)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.49
PTGDR2 Q9Y5Y4 4/20 0.46
CCNE1 P24864 2/20 0.43
CDK2 P24941 2/20 0.43
PPARG P37231 4/20 0.41
PPARA Q07869 4/20 0.41
RECQL P46063 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
PPARD Q03181 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
PDE4D Q08499 1/20 0.39
SLC40A1 Q9NP59 1/20 0.38
PKM P14618 1/20 0.38
HTR6 P50406 1/20 0.38
IDE P14735 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1773229 0.90 CYP2C19 (0.51) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL27681189 0.85 CYP2C19 (0.52) CYP2C19PTGDR2CCNE1CDK2PPARG
SCHEMBL30337641 0.81 CYP2C19 (0.56) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL1772416 0.81 CYP2C19 (0.56) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL2590156 0.77 CYP2C19 (0.55) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL1773438 0.77 CYP2C19 (0.55) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL30559878 0.77 CYP2C19 (0.55) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL28497684 0.77 CYP2C19 (0.55) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL23269048 0.76 ATM (0.53) CYP2C19PTGDR2CCNE1CDK2RECQL
SCHEMBL8688896 0.76 CYP2C19 (0.51) CYP2C19PTGDR2CCNE1CDK2RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0497516-A1 Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists MERCK & CO. INC. (US) 1992-08-05 EP disclosed
US-5124335-A Hypotensive agents, antiglaucoma agents MERCK & CO., INC. (US) 1992-06-23 US disclosed