Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM6A | O15550 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698993 | 0.84 | KDM4E (0.46) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL8129400 | 0.82 | KDM4E (0.44) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL9700172 | 0.81 | KDM4E (0.53) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL868431 | 0.80 | KDM4E (0.47) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL5512663 | 0.78 | MAPT (0.44) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL13555547 | 0.76 | KDM4E (0.44) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL6199498 | 0.75 | KDM4E (0.59) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL5525055 | 0.74 | KDM4E (0.62) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL9701411 | 0.74 | KDM4E (0.46) | KDM4EHTTTP53CYP2D6SMN1; SMN2 | |
| SCHEMBL3686713 | 0.74 | KDM4E (0.58) | KDM4EHTTTP53CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494754-A1 | 3-hydroxypyridin-4-one derivatives as pharmaceutical compositions | BRITISH TECHNOLOGY GROUP LTD (GB) | 1992-07-15 | — | — | EP | disclosed |